From the Del Sole motorway A1 take the exit Firenze Sud and go along the link road until the last traffic light. Here turn left and go straight ahead until the next traffic light, where you are obliged to turn right (opposite to the bridge of San Niccolò). Go along the Viali di Circonvallazione until you reach Piazza della Libertà (a square with an arch and a central fountain). Then follow the indication for Stazione Ferroviaria di Santa Maria Novella.
As you reach the end of Via Nazionale keep the left, pass the traffic light, turn at the rotunda and enter in Piazza dell'Unità (which has a central obelisk), go along in via del Melarancio (the first one way street), pass the little square and go along until the obligation to turn right and turn in Via Cerretani. The hotel is far just a few metres from here and it lies on your right side.
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Hotel Laurus Al Duomo, Via dè Cerretani, 54/R - Florence